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Hydrocephalus (Friesian, B3GALNT2)

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Hereditary developmental disorder of the Friesian with pathological accumulation of cerebrospinal fluid and a strongly enlarged skull of the foal, caused by a mutation in the B3GALNT2 gene and inherited autosomal-recessive. Affected foals are mostly not viable (often stillbirth); the enlarged head additionally means a considerable risk for a difficult birth (dystocia) and thus a danger for the mare.

Veterinary care required

This condition belongs in veterinary diagnosis and treatment. Compounds are at most supportive.

Priority · vet & management

On suspicion of a hydrocephalic foal, the birth is a veterinary emergency — because of the dystocia danger for the mare, call in the vet early. The disease is not curable and mostly lethal; for breeding, the carrier gene test of the parent animals is decisive.

Possible causes

  • · autosomal-recessive nonsense mutation in the B3GALNT2 gene
  • · only homozygous foals affected; carriers clinically healthy
  • · occurrence in the Friesian (narrow breeding base)
  • · enlarged head as the cause of a high dystocia risk

Supportive compounds · supplementary feed, not medication

Prevention

Gene testing of Friesian breeding animals and avoidance of carrier-x-carrier matings prevent affected foals and protect the mare from risky difficult births.

Equiterna's take

Equiterna accompanies Friesian hydrocephalus factually and honestly: the B3GALNT2 gene test, breeding management and the protection of the mare from dystocia are in the foreground — no promises of cure, no role for active substances.

Usage note

This content is for information and education. It does not replace veterinary diagnosis or treatment. If your horse shows signs of illness, consult a veterinarian.

Equiterna is an intermediary platform for equine knowledge, marketplace and tools — not a veterinary-medicines dealer, veterinary practice or pharmacy. Compound information is study-attributed and free of healing claims. Legal framework: Regulation (EU) 2019/6 / TAMG (DE/AT), Feed Regulation (EC) 767/2009, FEI Prohibited Substances List, HWG.