Dwarfism (Friesian, B4GALT7)
Hereditary skeletal/connective tissue disorder of the Friesian through a mutation in the B4GALT7 gene (disturbed build-up of proteoglycans of the cartilage/connective tissue matrix), inherited autosomal-recessive. Affected foals show shortened limbs with relatively normal trunk/head size as well as overextensible joints. Only homozygous animals are affected; carriers are unremarkable.
Veterinary care required
This condition belongs in veterinary diagnosis and treatment. Compounds are at most supportive.
Priority · vet & management
The work-up of a conspicuous foal belongs with the vet; the gene test secures the genetic classification. Dwarfism is not curable — in the foreground are veterinary support, an assessment of quality of life/resilience and the carrier test of the parent animals for breeding.
Possible causes
- · autosomal-recessive splice-site mutation in the B4GALT7 gene (proteoglycan linker disturbed)
- · only homozygous foals affected; carriers clinically unremarkable
- · occurrence in the Friesian (narrow breeding base)
- · manifestation early in foalhood, permanent
Supportive compounds · supplementary feed, not medication
Prevention
Gene testing of Friesian breeding animals and avoidance of carrier-x-carrier matings prevent affected foals.
Equiterna's take
Equiterna handles Friesian dwarfism genetics- and vet-centred: B4GALT7 gene test and breeding management are in the foreground — a predisposition of the breed is not a finding on the individual animal.
Usage note
This content is for information and education. It does not replace veterinary diagnosis or treatment. If your horse shows signs of illness, consult a veterinarian.
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